Obesity and breast cancer: inflammatory and adipocytokine correlations

Obesity and breast cancer: inflammatory and adipocytokine correlations

Obesity is a chronic disease affecting millions of individuals around the world and has taken epidemic proportions. Often, obesity is associated with other risk factors such as hypertension and dyslipidemia, increasing metabolic syndromerelated complications. Such complications include several cancer types, namely breast cancer. Several mechanisms are likely to be involved in cancer development...

Expression Study and Clinical Correlations of MYC and CCAT2 in Breast Cancer Patients

Background: Colon cancer-associated transcript 2 (CCAT2) is a newly recognized lncRNA transcribed from the 8q24 genomic region. It functions as an oncogene in various types of cancers including breast cancer, in which it affects Wnt/β-catenin pathway. Previous studies have shown a putative interaction between this lncRNA and MYC proto-oncogene. Methods: In the current study, we evaluated t...

Correlations of Diabetes and the Risk Factors with the Survival of Breast Cancer Patients

Introduction: Diabetes is associated with an increased risk of cancer. Because of the metastatic nature of cancer, the survival of women with breast cancer is decreasing despite receiving various treatments such as chemotherapy, radiotherapy, etc. The aim of this study was to investigate the relationship between diabetes and the risk factors related to the survival of breast cancer patients. M...

Breast Implants and Breast Cancer

Inflammatory breast cancer: yet another risk of the obesity epidemic?

p.P81S mutation presents with a milder degree of HIF 1/2 stabilization and activation of HIF target genes, providing a degree of pseudohypoxia that can still be modulated by actual hypoxia in the surrounding environment. The report also demonstrates that the VHL p.P81S and p.R167Q mutations result in the loss of interaction with Elongin C. A recent publication highlighted the mutation of this p...